Dean calls on Castiel, who tells Dean that Sam could kill Lilith but consuming that much Demon Blood would make him inhuman. Castiel says dean can be the one to stop the apocalypse, rather than Sam, and asks if Dean will do it. Dean agrees and swears fealty and obedience to God and the angels.

Later Castiel comes and uses his powers to release Sam's bonds and open the door Bobby's Panic Room. Anna visits Castiel, and confronts him over his actions, but he says he is acting on orders, and she is taken captive by other angels.